Health outcomes, education, healthcare delivery and quality – 3038: The relation of sTRAIL levels and quality of life in omalizumab using severe persistent allergic asthma patients

Background Omalizumab represents a novel approach to the treatment of asthma, inhibiting the inflammatory cascade before it starts. As it was previously reported, the increase in the eosinophil levels in allergic asthma was due to the increase in peripheral blood eosinophil survival promoted by TRAIL. And as an apoptotic molecule TRAIL also present in cells that involved in asthma including eosinophils, mast cells, fibroblasts, and airway epithelial cells. It is expressed in airway remodeling and may be linked with the pathways of TGF-b1, which is thought to cause damage to the epithelium. The repair process of the epithelium is hindered as a result of increased apoptosis induced by TGF-beta1, which overlaps with the pathways of TRAIL. Moreover analogs of TRAIL could have therapeutical applications for asthma.